Aug . 05, 2025 09:20 Back to list

Sodium Citrate Tube Uses in Blood Coagulation Testing

The sodium citrate tube used for blood collection and coagulation analysis is a staple in modern hematology, transfusion medicine, and laboratory diagnostics. With evolving regulatory standards (ISO 6710, FDA 21 CFR 864.9205), precise material control, and increasingly complex clinical demands, selecting the optimal sodium citrate tube impacts laboratory accuracy, cost efficiency, and patient safety. Sodium Citrate 1:4 Tube delivers a best-in-class solution for professional users in healthcare, petrochemical, water treatment, and metallurgy.

Industry Trends: The Growing Relevance of sodium citrate tube used for

In 2024, market demand for sodium citrate tube used for coagulation testing and citrated whole blood collection is projected to reach $380M globally (Markets&Markets, 2023). Key growth drivers include:

Stricter regulatory adoption (ISO, FDA, CE) for specimen traceability and safety.
Rise in complex hemostasis diagnostics (PT, APTT, Factor assays) and POCT devices.
Increasing automation in laboratories and emphasis on pre-analytical error elimination.
Industry crossover: Used in clinical labs, petrochemical safety labs, metallurgy R&D, and water treatment plant monitoring.

Key Terminology

Sodium Citrate Tube Used For: Collection of whole blood for coagulation studies by chelating calcium and preventing clotting.
Sodium Citrate Whole Blood: Blood collected with sodium citrate as anticoagulant, maintaining cell morphology and plasma components.
Sodium Citrate for Blood Collection: Tubes pre-filled with sodium citrate solution, available in various concentrations (commonly 0.109M or 3.2%).
Citrate Test Tube: Synonymous with sodium citrate tube, widely used in laboratory hematology.

Technical Specifications at a Glance

Proper tube selection ensures accurate test results and user safety. Explore comparative parameters:

Parameter	Sodium Citrate 1:4 Tube	Citrate Tube 1:9	EDTA Tube
Anticoagulant	Sodium Citrate 3.2% (1:4)	Sodium Citrate 3.2% (1:9)	K2EDTA
Material	Medical grade PET/Glass	Medical grade PET/Glass	Medical grade PET/Glass
Volume	2ml, 3ml, 4ml, 5ml	2ml, 3ml, 4ml, 5ml	2ml, 3ml, 4ml, 5ml
Color Code	Blue	Blue	Lavender
Application	Coagulation, platelet function	Coagulation testing	Hematology (CBC)
Certification	ISO 6710, CE, FDA	ISO 6710, CE	ISO 6710, CE, FDA

Manufacturing Process: How is a sodium citrate tube used for Created?

Modern sodium citrate tubes undergo precision manufacturing using medical-grade PET or borosilicate glass, ensuring chemical stability and minimal interaction with blood samples. The workflow integrates advanced machinery, quality assurance, and batch traceability:

Raw Material Selection (ISO 13485): Sourcing medical-grade plastic/glass cylinders.
Precision Cleaning: Automated ultrasonic or chemical wash for minimizing contamination.
CNC Filling: Robotic fluid station fills with accurate sodium citrate (3.2%, 1:4 ratio), minimizing volume errors (< ±1.5%).
Stoppering & Capping: Automated application of color-coded butyl-rubber stoppers and secure, leak-resistant caps.
Laser Labeling & Barcoding: GS1/UDI compliance for traceability.
Sterilization (Ethylene oxide/High-pressure steam, ISO 11135): Final sterilization to microbiological safety levels.
Inspection: QC for fill volume, color, label accuracy, and tube integrity with photographic AI.
Packing: Grouping in sealed, moisture- and light-resistant packs, with lot and expiry marking.

For process animation, visit: Manufacturing Video

Material: Polyethylene Terephthalate (PET) or Borosilicate Glass; tested for leachable elements as per EN ISO 1135 and ANSI/AAMI ST72.
Volume Accuracy: Assured at ±1.5% (industry-leading); impacts blood:citrate ratio for reliable results.
CNC Processing: Automation guarantees repeatability in solution dispensing.
Durability: Drop-tested; designed for 2-year shelf life under climate stress (ISO 11607-1:2019).

Application Scenarios for sodium citrate tube used for, with Real Data

Clinical Hematology: Routine coagulation panels (PT, APTT, D-dimer, fibrinogen) – accounts for >48% of sodium citrate tube global usage.
Blood Banks: Platelet function studies, crossmatch, apheresis quality control.
Industrial Labs: Petrochemical and metallurgy settings—detecting coagulopathies in exposure studies, corrosion monitoring (as plasma stability indicator).
Water Treatment/Wastewater R&D: Monitoring bio-markers of contamination and biofilm management in high-sensitivity environments (e.g. pharmaceutical water).

Sodium citrate whole blood maintains cell morphology and precise analyte concentrations for up to 4 hours at 20°C–24°C, enabling accurate transport and delayed analysis (ref: Clinical and Laboratory Standards Institute, CLSI H21-A5).

Data Visualization: Key Indices for sodium citrate tube used for

Frequently Searched Parameters
Parameter	Typical Value	Test Method
Citrate:BLOOD Ratio	1:4 (0.109M–0.111M Sodium Citrate)	Volumetric Fill Test
Tolerance	±1.5% fill	ISO 6710:2017
Material	PET/Glass, Medical Grade	EN ISO 1135-4
Cap Integrity	>2.5 kPa	ISO 6710 Pressure Test
pH Stability	6.5–7.5 (plasma)	ISO/TS 20914:2019
Certification	FDA, ISO, CE	Review

Supplier Comparison and Customization Capabilities

Choosing a reliable manufacturer for sodium citrate tube used for blood collection impacts both routine and specialized lab workflows.

Supplier	Certifications	CNC Precision	Custom Branding	MOQ	Lead Time (days)
BD Heating Pads	ISO 9001, ISO 13485, FDA, CE	±1.5% (industry top)	Yes (label/pack cap)	50,000	12–15
Greiner Bio-One	ISO 13485, CE	±2.0%	Yes	100,000	21–28
IMPROVACUTER (Chengdu)	CFDA, ISO 9001	±2.5%	Limited	10,000	18–22

BD Heating Pads offers all EN/ISO documentation for hospital and R&D tendering.
Rapid prototyping for new color codes or test volumes (7–10 days for small lots with customer logo).

Customization Project: Success Story in Petrochemical Quality Assurance

Case Study: Major Petrochemical Laboratory, Middle East (2023)

Challenge: Needed sodium citrate tube used for both routine coagulation and pyrogen detection, resistant to aggressive solvent residues.
Solution: Custom PET formula tube, 3.2% sodium citrate, extra-thick latex-free butyl stopper (ISO 11137), custom barcoding to integrate with LIMS.
Results: Achieved <1.3% sample rejection (vs typical 2%), improved TAT by 18%, and reduced annual tube waste by $12,940 USD.
Feedback: (“Excellent supplier, fully met compliance on ISO and customer label, risk-free audits.”)

Learn more about tailored sodium citrate tube used for solutions: Color-coded branding, volume adjustments, enhanced cap integrity, LIMS-compliant label printing, and sterile packaging on request.

FAQ & Technical Terminology

Q1: What is the main material used in sodium citrate tubes?

Medical-grade Polyethylene Terephthalate (PET) or Borosilicate glass, both certified under EN ISO 1135-4 for bio-compatibility and minimal leaching risk.

Q2: What specifications must a sodium citrate tube used for meet?

Must meet ISO 6710 (evacuated blood collection systems), offer fill accuracy <±1.5%, uniform sodium citrate molarity (0.109-0.111M), and color coding for rapid test distinction (blue cap).

Q3: What are typical dimensions/volumes for coagulation tubes?

Common internal volumes: 2ml, 3ml, 4ml, and 5ml. Outer diameter 13mm x 75mm or 16mm x 100mm, matching automated analyzer racks.

Q4: How is installation or integration in lab automation achieved?

Compatible with standard blood collection needles and Luer systems, barcoded for automated analyzers and LIMS software. Rigid sizing supports robotic pick-and-place arms.

Q5: How is the sterilization quality ensured?

Ethylene oxide or autoclave as per ISO 11135/ISO 11137, validated by biological indicators and batch testing for pyrogenicity.

Q6: What is your warranty/guarantee for the products?

All tubes are covered by a 24-month shelf-life warranty; batches are tracked by date/lot number; remains compliant to manufacturer COA and re-test certificates on request.

Q7: Are custom formulations or add-ons available?

Yes: Special citrate molarity, volume, PET wall thickness, cap types, dual labeling, and custom sterilization batch numbers can be negotiated for large R&D or industrial clients.

Delivery, Warranty, and Trusted Support

Delivery Cycle: Standard 50,000–200,000 tubes: 12–18 days. Custom print runs: 15–21 days. Priority air-freight available for urgent clinical needs.
Quality Guarantee: Full batch documentation, ISO/FDA/CE certification; on-site or remote inspection pre-shipment.
Customer Support: 24/7 response for technical and QA queries, dedicated account manager, fast batch recall and tracking.
After-sales: Tube performance claim rate

Testimonials & Industry Impact

“Implementation of BD Heating Pads’ sodium citrate tube used for products reduced coagulation sample error rate by 19%, improved blood volume accuracy, and seamlessly integrated with our laboratory automation. ISO compliance documentation was prompt and thorough – strongly recommended for high-throughput analytical labs.”
— Dr. Angela Riedl, Quality Manager, CoreLab GmbH

Long-term industrial clients in petrochemical, R&D, and centralized hospitals report significant savings on error mitigation, seamless LIMS data integration, and regulatory success using the sodium citrate 1:4 tube platform.